Researcher Determines Shape of a Protein Important for HIV and Cancer
Dr. Raymond C. Stevens at the Scripps Research Institute, funded in part by The Common Fund's Structural Biology Program, has determined the three-dimensional structure of CXCR4, a cellular protein important for HIV infection as well as the growth and metastasis of many types of cancer. In Stevens' most recent paper, published in the October 7 advance online issue of the journal Science, he describes the molecular structure of the CXCR4 protein bound to molecules known to inhibit CXCR4's function. Using knowledge of these binding sites, researchers may one day develop new strategies to design drugs that bind CXCR4 to block HIV infection or stall the spread of some cancers.
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