An NIH Workshop on Enhancing Collaboration with HMORN Research Organization, hosted by the National Institutes of Health (NIH), was held on March 15, 2010, on the NIH main campus in Bethesda, Maryland. The NIH convened a group of senior scientists, administrators, and policy makers from the HMO Research Network (HMORN), supported by the National Cancer Institute (NCI) and National Heart, Lung and Blood Institute (NHLBI), as well as the Centers for Medicare and Medicaid Services (CMS) and Agency for Healthcare Research and Quality (AHRQ), to identify opportunities and strategies to enhance coordination and research infrastructure of the HMORN to benefit research programs of many ICs. A meeting summary report was developed.