Monday, March 19, 2007
8:00 a.m.				Registration
8:30 - 8:50 a.m.				Welcome and Charge to the Group David A. Schwartz, M.D. Director National Institute of Environmental Health Sciences (NIEHS) Nora D. Volkow, M.D. Director National Institute on Drug Abuse (NIDA)
8:50 - 9:00 a.m.				Introductions
9:00 - 9:30 a.m.				Phenotypic Plasticity and the Epigenetics of Human Disease Andrew P. Feinberg, M.D., Ph.D. Johns Hopkins University School of Medicine
9:30 - 9:45 a.m.				Break
9:45 - 11:00 a.m.				Scientific Session 1: Applications to Human Health and Disease How Can the Application of Epigenetic Approaches Advance Our Understanding of Disease Susceptibility and Pathogenesis?
9:45 - 10:10 a.m.				Mixed Epigenetic/Genetic and De novo/Inherited (MEGDI) Models of Disease Arthur L. Beaudet, M.D. Baylor College of Medicine
10:10 - 10:35 a.m.				Epigenetics and Autoimmunity Bruce Richardson, M.D., Ph.D. University of Michigan
10:35 - 11:00 a.m.				Epigenetic Mechanisms of Drug Addiction Eric J. Nestler, M.D., Ph.D. University of Texas, Southwestern
11:00 - 11:15 a.m.				Break
11:15 - 12:30 p.m.				Scientific Session 2: The State of Epigenetic Technology What Technologies and Investigative Approaches to Research Are Available and Likely To Be of Value in Epigenetics?
11:15 - 11:40 a.m.				Overview of Epigenetic Analysis Technologies Peter W. Laird, Ph.D. University of Southern California
11:40 a.m. - 12:05 p.m.				Genome-wide Transcription Maps Reveal Interleaved Organization and Possible Functions for Pervasive Transcription Thomas R. Gingeras, Ph.D. Affymetrix, Inc.
12:05 - 12:30 p.m.				Mapping the Genome's Second Code Bing Ren, Ph.D. University of California, San Diego
12:30 - 1:45 p.m.				Lunch (on your own)
1:45 - 2:45 p.m.				Overview: International and U.S. Epigenetics Programs and Resources
1:45 - 2:00 p.m.				European Epigenetics Programs Stephan Beck, Ph.D. Wellcome Trust Sanger Institute
2:00 - 2:15 p.m.				Epigenetics Bioinformatics Resources Paul Flicek, D.Sc. European Bioinformatics Institute
2:15 - 2:30 p.m.				Canadian Epigenetics Programs Art Petronis, M.D., Ph.D. University of Toronto
2:30 - 2:45 p.m.				Epigenetics and the ENCODE Project Elise A. Feingold, Ph.D. National Human Genome Research Institute
2:45 - 3:00 p.m.				Break
3:00 - 3:10 p.m.				Criteria for Roadmap Proposals Elizabeth Wilder, Ph.D. Office of Portfolio Analysis and Strategic Initiatives (OPASI)
3:10 - 5:10 p.m.				Breakout Session 1: Generation of Epigenetics Suggestions Breakout Discussion Group A Chair: David Schwartz, M.D., NIEHS Director Presenter: Steven Baylin, M.D. Breakout Discussion Group B Chair: Nora Volkow, M.D., NIDA Director Presenter: Donata Vercelli, M.D. Breakout Discussion Group C Chair: James Battey, M.D., Ph.D., NIDCD Director Presenters: Randy Jirtle, Ph.D. and Jim Ostell, Ph.D.
3:10 - 3:50 p.m.				Generate three novel Roadmap suggestions for epigenetics research that could transform the biology of human health and disease, encompassing translational and clinically-oriented approaches.
3:50 - 4:30 p.m.				Generate three novel Roadmap suggestions for tools and resources that could transform epigenetics research.
4:30 - 5:10 p.m.				Generate three novel Roadmap suggestions for technological and bioinformatics needs that could transform epigenetics research.
5:10 - 5:25 p.m.				Break
5:25 - 5:40 p.m.				Breakout Group A Report Presenter: Steven Baylin, M.D.
5:40 - 5:55 p.m.				Breakout Group B Report Presenter: Donata Vercelli, M.D.
5:55 - 6:10 p.m.				Breakout Group C Report Presenters: Randy Jirtle, Ph.D. and Jim Ostell, Ph.D.
6:10 - 6:30 p.m.				Group Discussion Facilitators: James Battey, M.D., Ph.D., Andrew Feinberg, M.D., Ph.D. and Jim Ostell, Ph.D.
6:30 - 6:45 p.m.				Response to Suggestions David Schwartz, M.D., NIEHS Director Nora Volkow, M.D., NIDA Director
6:45 p.m.				Adjournment

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Tuesday, March 20, 2007
7:30 a.m.				Registration
8:00 - 9:45 a.m.				Breakout Session 2: Implementation of Suggestions
8:00 - 8:35 a.m.				Implement a suggestion for a technology/bioinformatics opportunity that could transform epigenetics research.
8:35 - 9:10 a.m.				Implement a suggestion for a tool or resource that could transform epigenetics research.
9:10 - 9:45 a.m.				Implement a suggestion for an application of epigenetics that could transform biology or treatment of disease.
9:45 - 10:00 a.m.				Break
10:00 - 10:20 a.m.				Breakout Group A Report Presenter: Steven Baylin, M.D.
10:20 - 10:40 a.m.				Breakout Group B Report Presenter: Donata Vercelli, M.D.
10:40 - 11:00 a.m.				Breakout Group C Report Presenters: Randy Jirtle, Ph.D. and Jim Ostell, Ph.D.
11:00 - 11:15 a.m.				Break
11:15 a.m. - 12:15 p.m.				Group Discussion and Refinement of Suggestions Facilitators: James Battey, M.D., Ph.D., Andrew Feinberg M.D., Ph.D. and Jim Ostell, Ph.D.
12:15 - 12:30 p.m.				Response to Suggestions and Closing Remarks David Schwartz, M.D., NIEHS Director Nora Volkow, M.D., NIDA Director
12:30 p.m.				Adjournment

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