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Epigenetics of Human Health and Disease

March 19-20, 2007, Bethesda North Marriott Hotel & Conference Center

 
Monday, March 19, 2007
8:00 a.m. Registration
8:30 - 8:50 a.m. Welcome and Charge to the Group
David A. Schwartz, M.D.
Director
National Institute of Environmental Health Sciences (NIEHS)

Nora D. Volkow, M.D.
Director
National Institute on Drug Abuse (NIDA)

8:50 - 9:00 a.m. Introductions
9:00 - 9:30 a.m. Phenotypic Plasticity and the Epigenetics of Human Disease
Andrew P. Feinberg, M.D., Ph.D.
Johns Hopkins University School of Medicine
9:30 - 9:45 a.m. Break
9:45 - 11:00 a.m. Scientific Session 1: Applications to Human Health and Disease
How Can the Application of Epigenetic Approaches Advance Our Understanding of Disease Susceptibility and Pathogenesis?
9:45 - 10:10 a.m. Mixed Epigenetic/Genetic and De novo/Inherited (MEGDI) Models of Disease
Arthur L. Beaudet, M.D.
Baylor College of Medicine
10:10 - 10:35 a.m. Epigenetics and Autoimmunity
Bruce Richardson, M.D., Ph.D.
University of Michigan
10:35 - 11:00 a.m. Epigenetic Mechanisms of Drug Addiction
Eric J. Nestler, M.D., Ph.D.
University of Texas, Southwestern
11:00 - 11:15 a.m. Break
11:15 - 12:30 p.m. Scientific Session 2: The State of Epigenetic Technology
What Technologies and Investigative Approaches to Research Are Available and Likely To Be of Value in Epigenetics?
11:15 - 11:40 a.m. Overview of Epigenetic Analysis Technologies
Peter W. Laird, Ph.D.
University of Southern California
11:40 a.m. - 12:05 p.m. Genome-wide Transcription Maps Reveal Interleaved Organization and Possible Functions for Pervasive Transcription
Thomas R. Gingeras, Ph.D.
Affymetrix, Inc.
12:05 - 12:30 p.m. Mapping the Genome's Second Code
Bing Ren, Ph.D.
University of California, San Diego
12:30 - 1:45 p.m. Lunch (on your own)
1:45 - 2:45 p.m. Overview: International and U.S. Epigenetics Programs and Resources
1:45 - 2:00 p.m. European Epigenetics Programs
Stephan Beck, Ph.D.
Wellcome Trust Sanger Institute
2:00 - 2:15 p.m. Epigenetics Bioinformatics Resources
Paul Flicek, D.Sc.
European Bioinformatics Institute
2:15 - 2:30 p.m. Canadian Epigenetics Programs
Art Petronis, M.D., Ph.D.
University of Toronto
2:30 - 2:45 p.m. Epigenetics and the ENCODE Project
Elise A. Feingold, Ph.D.
National Human Genome Research Institute
2:45 - 3:00 p.m. Break
3:00 - 3:10 p.m. Criteria for Roadmap Proposals
Elizabeth Wilder, Ph.D.
Office of Portfolio Analysis and Strategic Initiatives (OPASI)
3:10 - 5:10 p.m. Breakout Session 1: Generation of Epigenetics Suggestions

Breakout Discussion Group A
Chair: David Schwartz, M.D., NIEHS Director
Presenter: Steven Baylin, M.D.

Breakout Discussion Group B
Chair: Nora Volkow, M.D., NIDA Director
Presenter: Donata Vercelli, M.D.

Breakout Discussion Group C
Chair: James Battey, M.D., Ph.D., NIDCD Director
Presenters: Randy Jirtle, Ph.D. and Jim Ostell, Ph.D.

3:10 - 3:50 p.m. Generate three novel Roadmap suggestions for epigenetics research that could transform the biology of human health and disease, encompassing translational and clinically-oriented approaches.
3:50 - 4:30 p.m. Generate three novel Roadmap suggestions for tools and resources that could transform epigenetics research.
4:30 - 5:10 p.m. Generate three novel Roadmap suggestions for technological and bioinformatics needs that could transform epigenetics research.
5:10 - 5:25 p.m. Break
5:25 - 5:40 p.m. Breakout Group A Report
Presenter: Steven Baylin, M.D.
5:40 - 5:55 p.m. Breakout Group B Report
Presenter: Donata Vercelli, M.D.
5:55 - 6:10 p.m. Breakout Group C Report
Presenters: Randy Jirtle, Ph.D. and Jim Ostell, Ph.D.
6:10 - 6:30 p.m. Group Discussion
Facilitators: James Battey, M.D., Ph.D., Andrew Feinberg, M.D., Ph.D. and Jim Ostell, Ph.D.
6:30 - 6:45 p.m. Response to Suggestions
David Schwartz, M.D., NIEHS Director
Nora Volkow, M.D., NIDA Director
6:45 p.m. Adjournment

 

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Tuesday, March 20, 2007
7:30 a.m. Registration  
8:00 - 9:45 a.m. Breakout Session 2: Implementation of Suggestions  
8:00 - 8:35 a.m. Implement a suggestion for a technology/bioinformatics opportunity that could transform epigenetics research.  
8:35 - 9:10 a.m. Implement a suggestion for a tool or resource that could transform epigenetics research.  
9:10 - 9:45 a.m. Implement a suggestion for an application of epigenetics that could transform biology or treatment of disease.  
9:45 - 10:00 a.m. Break  
10:00 - 10:20 a.m. Breakout Group A Report
Presenter: Steven Baylin, M.D.
 
10:20 - 10:40 a.m. Breakout Group B Report
Presenter: Donata Vercelli, M.D.
 
10:40 - 11:00 a.m. Breakout Group C Report
Presenters: Randy Jirtle, Ph.D. and Jim Ostell, Ph.D.
 
11:00 - 11:15 a.m. Break  
11:15 a.m. - 12:15 p.m. Group Discussion and Refinement of Suggestions
Facilitators: James Battey, M.D., Ph.D., Andrew Feinberg M.D., Ph.D. and Jim Ostell, Ph.D.
 
12:15 - 12:30 p.m. Response to Suggestions and Closing Remarks
David Schwartz, M.D., NIEHS Director
Nora Volkow, M.D., NIDA Director
 
12:30 p.m. Adjournment  

 

 

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