- My grant activity code is not listed in the announcement as an eligible activity code. Is my grant eligible for an administrative supplement via this Notice (PA-12-119)?
Unfortunately, if your grant’s activity code is not specifically listed in the announcement, it is not eligible for supplemental funding made available as part of this announcement.
Grant awards that are not eligible include:
- Career Development Awards (K)
- Research Training Grant Awards (F, T)
- Linked Awards (UL, RL, KL)
- Small Research Project Grant Awards (R03)
- U10 Awards
- ARRA-funded Awards (e.g., RC activity code)
- I understand that supplemental work must fall within the scope of the original aims of the parent study. How do I assess whether or not my supplemental work is within scope?
The assessment of whether supplemental work is within the scope of the parent grant aims is made by the Program Officer/Program Director and Grants Management Official responsible for the parent grant award. Applicants are highly encouraged to talk with the NIH staff administering the parent grant award. Contact information for the program and grants officials can be found on the Notice of Grant Award, and on eRA Commons.
Generally, supplemental work is considered outside the scope of the original project when it proposes make substantive changes to the parent project that affect safety of participants or the direction of the science.
Generally, supplemental work is considered within the scope of the original project when it proposes to address the parent-grant aims with additional methods and participants from a similar target population as the parent grant.
- I am already manipulating putative mechanisms of action in my currently-funded behavioral intervention grant, but couldn’t include as many measures in the original grant proposal as I had hoped. May I propose to use supplemental funds to add more measures, or more frequent measurement, of the hypothesized mechanism?
While measurement is an important part of mechanisms of action research, it is not the specific focus of this announcement. Generally, this announcement does not provide support for adding measures to an existing study even if the parent study already manipulates and measures an intervention’s hypothesized mechanism(s) of action. The one exception to this is when the proposed added measure is on a different level of analysis than the original measures AND investigators develop a clear explanation of how the added measure is likely to increase knowledge on why the intervention works.
- I am already conducting a randomized controlled study where I compare two interventions derived from two different theoretical models. Does it mean that I am already manipulating putative mechanisms of action?
Most interventions are multi-component. Manipulating multi-component interventions is not the same as manipulating a putative change mechanism of an intervention.
- I am the Principle Investigator on an early-stage behavioral intervention research grant. The currently-funded grant is meant to develop the intervention, using methods such as focus groups and small-scale acceptability testing of a draft intervention manual. Could I apply for supplemental funding as part of this announcement?
If you can meet the requirements of the announcement, you may be eligible to apply. Those requirements are:
- explicate a rationale for why the intervention is hypothesized to work;
- run an experiment where you manipulate a hypothesized mechanism;
- include a manipulation check; and
- test for predicted associations between the hypothesized mechanism and outcomes
- Clinical observations suggest that socioeconomic status (SES) may predict differential responses to the behavioral intervention we are testing in a currently-funded behavioral intervention study. Could we propose to add indicators of SES in response to this announcement, and test for significant moderation effects?
If SES is conceptualized as a moderator, such that individuals at different levels of SES are predicted to respond differently to the intervention, simply adding measures of SES and testing for moderation would not be appropriate for this announcement. If, however, SES moderation of treatment response led the team to hypothesize a mechanism of action (e.g., the intervention works by strengthening social norms, or teaching new skills, or decreasing conflict in families), the team might propose to manipulate that hypothesized mechanism, in accordance with the announcement. (See also self-guided technical assistance PowerPoint slide #9).
- The initial period of my grant is expiring soon, but I plan to request a no-cost extension year. May I still apply for supplemental funding in response to this announcement?
A supplement award cannot be made to a grant in a no-cost extension period. The parent grant may be eligible for supplemental funds if it will be active through at least July of 2013.
- My current intervention grant expires in the Fall of 2013, but I plan to request a no-cost extension year. May I propose supplemental work that extends into the no-cost extension year?
Supplement proposals must describe work that can be reasonably completed during the active period of the parent grant, without extending into the no-cost extension period.
- I have several years left on my current intervention grant, and I think the supplemental work may take more than 1 year. May I propose supplemental work that spans 2 years?
Although this announcement is intended to support 1-year awards, if there is an exceptional need or opportunity for supplemental work that spans more than 1 year, such proposals may be submitted.