Trypanosomes and immune cells (B cells)

Building novel vaccines on a borrowed coat

African trypanosomes are blood-borne parasites that use their surface coat as a decoy to trick the immune system into making long-lasting antibody responses. Image shows trypanosomes surrounded by immune cells (B cells). Trypanosome coats will be modified (shown in the middle panel) to trick the immune system into making therapeutic antibodies against disease-associated targets (inserted epitope, shown in the right panel).