Funded Research

NIH Director's Transformative Research Awards (R01) RFA-RM-11-006
PI Name	Institution Name	Title
ABELIOVICH, ASA	COLUMBIA UNIVERSITY HEALTH SCIENCES	Generation and integration of new CNS neurons by in vivo directed conversion
ALLISON, DAVID B	UNIVERSITY OF ALABAMA BIRMINGHAM	Energetics, Disparities, & Lifespan: A unified hypothesis
ALTSHULER, DAVID (contact) COWAN, CHAD ALBERT	THE BROAD INSTITUTE, INC.	Isogenic Human Pluripotent Stem Cell-Based Models of Human Disease Mutations
BARRES, BEN A	STANFORD UNIVERSITY	An Astrocytic Basis for Humanity
BLAU, HELEN M	STANFORD UNIVERSITY	Telomere extension using nucleoside-modified mRNA and exosomes as a novel therape
BROWN, EMERY N. (contact) BOYDEN, EDWARD S. SOLT, KEN WILSON, MATTHEW A.	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Redesigning General Anesthesia
CHRISTMAN, KAREN L (contact) GIANNESCHI, NATHAN CLAUDE	UNIVERSITY OF CALIFORNIA SAN DIEGO	Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction
DARNELL, ROBERT B	THE ROCKEFELLER UNIVERSITY	Mapping the mechanisms of protein synthesis-dependent synaptic plasticity
DEISSEROTH, KARL ALEXANDER	STANFORD UNIVERSITY	CLARITY: fully-assembled biology
GEREAU, ROBERT W (contact) BRUCHAS, MICHAEL R ROGERS, JOHN	WASHINGTON UNIVERSITY	Multimodal biocompatible microLED devices for diverse neuroscience applications
GLASS, CHRISTOPHER K	UNIVERSITY OF CALIFORNIA SAN DIEGO	Enhancer Therapy
MARASCO, PAUL	CLEVELAND VA MEDICAL RESEARCH/ED/FDN	Restoring upper limb movement sense to amputees; a move towards natural control of prosthetic limbs
NEWMAN, DIANNE K	CALIFORNIA INSTITUTE OF TECHNOLOGY	Geobiological approaches to understanding pulmonary infections in situ
SHEA, LONNIE D (contact) BACKMAN, VADIM	NORTHWESTERN UNIVERSITY	An in vivo metastasis sensor
SHEVKOPLYAS, SERGEY S	TULANE UNIVERSITY OF LOUISIANA	Eliminating Mediators of Toxicity from Stored Blood
STOJANOVIC, MILAN N (contact) YAN, HAO	COLUMBIA UNIVERSITY HEALTH SCIENCES	Theranostic Nano-objects: Basic Principles and Initial Applications
TUSCHL, THOMAS (contact) OHLER, UWE PATEL, DINSHAW J	THE ROCKEFELLER UNIVERSITY	Posttranscriptional regulation by mRNA-binding shuttling and transport proteins
WEINER, HOWARD L	BRIGHAM AND WOMEN'S HOSPITAL, INC	Role of the Innate Immune System in Aging and Development of Alzheimer's Disease
WISNIEWSKI, NATALIE ANN (contact) MCSHANE, MIKE	PROFUSA, INC.	Implantable multi-analyte sensors for the continuous monitoring of body chemistries
WUCHERPFENNIG, KAI W (contact) GOTTSCHALK, STEPHEN	DANA-FARBER CANCER INSTITUTE	Reprogramming of T cells for the Treatment of Melanoma

NIH Common Fund Transformative Research Projects Program (R01) RFA-RM-10-010
PI Name	Institution Name	Title
BEN-YAKAR, ADELA (contact) PIERCE-SHIMOMURA, JONATHAN T	UNIVERSITY OF TEXAS AUSTIN	High-speed opto-fluidics to screen entire nervous system in aging and disease
BOAHEN, KWABENA	STANFORD UNIVERSITY	Fully Implantable and Programmable Spike-based Codecs for Neuroprosthetics
GAGE, FRED H	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Single-Cell Approaches to Reveal How Jumping Genes Individualize Neural Circuits
HARTUNG, THOMAS	JOHNS HOPKINS UNIVERSITY	Mapping the Human Toxome by Systems Toxicology
HONKANEN, RICHARD E	UNIVERSITY OF SOUTH ALABAMA	Methods to enable cholesterol catabolism in human monocyte derived macrophages
JASANOFF, ALAN	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Noninvasive imaging-based electrophysiology using microelectronic devices
KUPPER, THOMAS S	BRIGHAM AND WOMEN'S HOSPITAL	Vaccination to generate protective tissue resident T cells
LECKMAN, JAMES F (contact) WEXLER, BRUCE E.	YALE UNIVERSITY	Integrated Brain, Body and Social Intervention for ADHD
LICHTMAN, JEFF W (contact) MEISTER, MARKUS SANES, JOSHUA R SEUNG, H SEBASTIAN	HARVARD UNIVERSITY	High Resolution Connectomics of Mammalian Neural Circuits
LIN, HENING (contact) CERIONE, RICHARD A WEISS, ROBERT S	CORNELL UNIVERSITY ITHACA	Succinylation and Malonylation as Novel Protein Modifications in Cancer
MCDEVITT, TODD C	GEORGIA INSTITUTE OF TECHNOLOGY	Stem Cell Morphogen Delivery via Engineered Biomaterials
MOOTHA, VAMSI KRISHNA	MASSACHUSETTS GENERAL HOSPITAL	Molecular prostheses for mitochondrial disorders
NIE, SHUMING (contact) SINGHAL, SUNIL	EMORY UNIVERSITY	Contrast-Enhanced and Image-Guided Surgery of Lung Cancer
NOLTA, JAN A	UNIVERSITY OF CALIFORNIA DAVIS	Direct cell to cell transfer of microRNA for tissue repair
PAPAVASILIOU, F NINA	ROCKEFELLER UNIVERSITY	Building novel vaccines on a borrowed coat
PUGLISI, JOSEPH D	STANFORD UNIVERSITY	Single molecule translational profiling
ROSS, MARGARET ELIZABETH (contact) MASON, CHRISTOPHER EDWARD	WEILL MEDICAL COLLEGE OF CORNELL UNIV	Epigenome Interactions in Complex Neurogenetic Disorders

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Roadmap Transformative Research Projects Program (R01) RFA-RM-09-022
PI Name	Institution Name	Title
ARLOTTA, PAOLA (contact) JOUNG, J. KEITH ZHANG, FENG	MASSACHUSETTS GENERAL HOSPITAL	Genome-wide Light-inducible Tuning of Transcriptional Network Dynamic
BLASER, MARTIN J	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Disappearing gastrointestinal microbiota in epidemic obesity
COUKOS, GEORGE	UNIVERSITY OF PENNSYLVANIA	Transformative personalized vascular disrupting cancer immunotherapy
ELLINGTON, ANDREW D	UNIVERSITY OF TEXAS AUSTIN	DNA circuits for point-of-care diagnostics
FLAVELL, RICHARD A (contact) DHODAPKAR, MADHAV V	YALE UNIVERSITY	Understanding Hemotopoietic Neoplasias using Humanized Mice
GREEN, PAMELA J	UNIVERSITY OF DELAWARE	Global Analysis of the Human RNA Degradome
GRUTZENDLER, JAIME	NORTHWESTERN UNIVERSITY	Embolus extravasation: an alternative mechanism of microvascular recanalization
KEATING, AMY E	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Very large datasets and new models to predict and design protein interactions
NICKELS, BRYCE EDWARD (contact) DOVE, SIMON L	RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK	NanoRNA-mediated control of gene expression
NICOLELIS, MIGUEL A. L.	DUKE UNIVERSITY	Dorsal Column Stimulation as a New Therapy for Motor Disorders
OLTZ, EUGENE M. (contact) PAYTON, JACQUELINE E	WASHINGTON UNIVERSITY	Targeting Epigenomic Signatures in Non-Hodgkin Lymphoma for Novel Therapeutics
PELTZ, GARY A	STANFORD UNIVERSITY	Human Pharmacogenetics and Human Liver Regeneration
SHAHAM, SHAI	ROCKEFELLER UNIVERSITY	Glial control of neuronal receptive ending morphology
WANG, LIGUO	YALE UNIVERSITY	Structure of a membrane protein in a lipid membrane: cryo-EM study of the HCN cha
WEINER, DAVID B	UNIVERSITY OF PENNSYLVANIA	Development of a Universal Influenza Seasonal Vaccine
WERNIG, MARIUS (contact) SUDHOF, THOMAS C	STANFORD UNIVERSITY	Direct conversion of fibroblasts into neurons: A novel approach to study neuropsy
YANIK, MEHMET FATIH	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	High-Throughput in Vivo Subcellular-Resolution Vertebrate Screening Platform
ZADOR, ANTHONY M	COLD SPRING HARBOR LABORATORY	High-throughput DNA sequencing method for probing the connectivity of neural circ
ZHANG, KANG (contact) DING, SHENG REH, THOMAS A	UNIVERSITY OF CALIFORNIA SAN DIEGO	Regeneration of Retinal Neurons by Chemically Induced Reprogramming of Muller Gli
ZHUANG, XIAOWEI (contact) XIE, XIAOLIANG SUNNEY	HARVARD UNIVERSITY	Dynamic cellular architecture of bacteria by system-wide super-resolution imaging

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Roadmap Transformative R01 Program (R01) RFA-RM 08-029
PI Name	Institution Name	Title
AUSUBEL, FREDERICK M	MASSACHUSETTS GENERAL HOSPITAL	Identifying novel anti-infectives by high through-put screening in whole animals
.BRETON, SYLVIE	MASSACHUSETTS GENERAL HOSPITAL	3-Dimensional modeling of basal cell function in pseudostratified epithelia
CAMARERO, JULIO A	UNIVERSITY OF SOUTHERN CALIFORNIA	Cell-based screening and selection of cyclotide-based capture reagents for protein profiling using micro-array format
COHEN, PINCHAS	UNIVERSITY OF CALIFORNIA LOS ANGELES	Novel Mitochondrially Encoded Peptides and Their Role in Health and Disease
CRAVATT, BENJAMIN F. (contact); KODADEK, THOMAS J	SCRIPPS RESEARCH INSTITUTE	Massively Parallel Identification of Protein Ligands
CZECH, MICHAEL P	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Oral Delivery Vehicles for RNAi Therapies
DANUSER, GAUDENZ (contact); HAHN, KLAUS MICHAEL	SCRIPPS RESEARCH INSTITUTE	Quantitative Imaging of Signaling Networks
DUBNAU, JOSHUA T	COLD SPRING HARBOR LABORATORY	Genome-wide regulatory network governing neuronal mRNA translation.
FIDOCK, DAVID ARMAND	COLUMBIA UNIVERSITY HEALTH SCIENCES	Exploiting Fatty Acid Metabolism To Cure Malaria
GRIFFITH, LINDA G.	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Perfused 3D Tissue Surrogates for Complex Cell-Cell Communication Systems
HOFFMAN, ANDREW R	STANFORD UNIVERSITY	Role of Long-Range Chromatin Interactions in Genetic Disease
YENGAR, SRINIVAS RAVI V (contact); HE, JOHN C HONE, JAMES C LOEW, LESLIE M NEVES, SUSANA R	MOUNT SINAI SCHOOL OF MEDICINE OF NYU	Dynamics Underlying Tissue Integrity
JAFFREY, SAMIE R	WEILL MEDICAL COLLEGE OF CORNELL UNIV	Novel fluorescent sensors for simple, sensitive, and specific protein detection
JI, RU-RONG (contact) SERHAN, CHARLES NICHOLAS	BRIGHAM AND WOMEN'S HOSPITAL	Resolvins, protectins, and chronic pain resolution
KOIDE, SHOHEI	UNIVERSITY OF CHICAGO	Rational generation of directed protein-capture reagents
KUO, CALVIN J	STANFORD UNIVERSITY	Three-dimensional Scaffold-based Systems for Primary Human Intestinal Culture
LAGASSE, ERIC	VA PALO ALTO HEALTH CARE SYSTEM	Organogenesis of Ectopic Tissue in Lymph Node
LEE, BRENDAN HL	BAYLOR COLLEGE OF MEDICINE	Argininosuccinate Lyase is an essential regulator of systemic nitric oxide production
LEE, FRANK S	UNIVERSITY OF PENNSYLVANIA	The Hydroxylprolylproteome
LEWIS, KIM	NORTHEASTERN UNIVERSITY	Super-persistent cells and the paradox of untreatable infections
LI, LONG-CHENG (contact); LI, HAO	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Transcriptional Activation by Small RNA: Mechanism and Design Rules
LIS, JOHN T (contact); CRAIGHEAD, HAROLD G JIN, MOONSOO M	CORNELL UNIVERSITY	Development of High Throughput Aptamer-based Protein Capture/Detection Assays towards Comprehensive Analysis of Human Proteome
MACIEJEWSKI, JAROSLAW P	CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE	Viral Pathogenesis of Idiopathic Bone Marrow Failure and Immune Cytopenias
MARGOLIS, PETER ADAM (contact); SEID, MICHAEL	CHILDREN'S HOSPITAL MEDICAL CTR (CINCINNATI)	Open Source Science: Transforming Chronic Illness Care
MARKOVITZ, DAVID MICHAEL	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Replication of Human Endogenous Retroviruses in Modern Humans
MARKOWITZ, SANFORD D	CASE WESTERN RESERVE UNIVERSITY	Identifying Inborn Genetic Susceptibility to Development of Cancer Metastasis
MARSHALL, WALLACE	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Pattern formation & regeneration in a single cell
MITRA, PARTHA PRATIM	COLD SPRING HARBOR LABORATORY	The Missing Circuit: The First Brainwide Connectivity Map for Mouse
MURDOCK, DEBORAH G	VANDERBILT UNIVERSITY MEDICAL CENTER	Fatty acid signals as quorum sensing regulators of mitochondrial biogenesis
MURPHY, SHEILA T. (contact); BAEZCONDE GARBANATI, LOURDES ALBERTINA BALL-ROKEACH, SANDRA HAILE, ROBERT WILLIAM	UNIVERSITY SOUTHERN CALIFORNIA	Transforming Cancer Knowledge, Attitudes and Behavior through Narrative
NISWENDER, KEVIN D (contact); GALLI, AURELIO ANTONIO	VANDERBILT UNIVERSITY	Insulin regulation of monoamine signaling: pathway to obesity
PARSONNET, JULIE	STANFORD UNIVERSITY	Childhood infection and prevention of obesity
POLLACK, GERALD H	UNIVERSITY OF WASHINGTON	Unexpectedly Profound Role of Water in Biology and Medicine
RICE, CHARLES M. (contact); BHATIA, SANGEETA N.	ROCKEFELLER UNIVERSITY	Modeling human hepatotropic infections in complex tissue organoids
ROBERTS, RICHARD W (contact); SOH, HYONGSOK TOM	UNIVERSITY SOUTHERN CALIFORNIA	Polypeptide Design with Proteomic Scope via Microfluidic mRNA Display
SUKI, BELA	BOSTON UNIVERSITY	Regulatory roles of variable mechanical stimuli in cell function
TEWARI, MUNEESH	FRED HUTCHINSON CANCER RESEARCH CENTER	RNA as a Hormone: Systemic Signaling in Mammals via Circulating, Cell-Free Small
WALENSKY, LOREN D	DANA-FARBER CANCER INSTITUTE	A Lexicon of Stapled Peptide Helices Engineered to Capture the Protein Interactome
WILSON, ROBERT B	UNIVERSITY OF PENNSYLVANIA	Random shRNA Selection
WU, JOSEPH C	STANFORD UNIVERSITY	Re-Education of the Immune System for hES Cell Tolerance
XIE, XIAOLIANG SUNNEY	HARVARD UNIVERSITY	maging the Invisible with No Labels: A Major Opportunity in Biology and Medicine
ZYLKA, MARK JOHN	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Harnessing ectonucleotidases to treat chronic pain

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