Transformative R01 Program

PATTERN FORMATION & REGENERATION IN A SINGLE CELL

PATTERN FORMATION & REGENERATION IN A SINGLE CELL

‚ÄčThis single Stentor cell is stained with antibodies to acetylated tubulin (red), the centriole protein POC1 (green), and with the DNA stain DAPI which stains the nuclei blue. The stripes are rows of cilia running along the anterior-posterior axis of the cell. The whorls visible at one end of the cell are the oral apparatus, a complex sub-cellular structure containing tens of thousands of centrioles and cilia, which can regenerate in a matter of hours if it is severed. The goal is to understand how such complex regenerative processes take place within single cells, thus providing a new way of looking at questions of regeneration, development, and wound healing, that are normally only addressed at the level of tissues and organs.