Transformative R01 Program
RE-EDUCATION OF THE IMMUNE SYSTEM FOR HES CELL TOLERANCE
Before human embryonic stem cell-based therapies (e.g., for such conditions as neuronal disease, cardiovascular disease, diabetes, Parkinson's, among others) can be translated into the clinic, new strategies that can overcome the immunological barrier must be developed. To address this bottleneck, this proposal will focus on developing novel and effective strategies to induce immunological tolerance for human embryonic stem cell therapy. The ability to overcome the immunological barrier will represent a major scientific advance in stem cell biology.