Transformative R01 Program

THE HYDROXYLPROLYLPROTEOME

THE HYDROXYLPROLYLPROTEOME

​​Shown is the structure of a Hypoxia Inducible Factor-1a (HIF-1a) peptide bound to the von Hippel Lindau (VHL) protein. Hydroxylproline-564 (Hyp-564, highlighted in yellow) of HIF-1a occupies a Hyp-binding pocket of VHL. Image was generated using Cn3D and PDB ID 1LM8 (Min et al., 2002, Science 296, 1886).