Transformative R01 Program
EXPLOITING FATTY ACID METABOLISM TO CURE MALARIA
Infection begins when Plasmdium parasites are injected as sporozoite forms into the human skin, through the bite of infected Anopheles mosquito. After inoculation, these parasites migrate to liver cells, where they establish the first intracellular replicative stage. Upon maturation, merozoites are released from the infected liver cells. They then invade red blood cells (RBCs), producing asexual blood stage forms. These can lodge in tissues and cause disease symptoms that can be fatal. The life cycle is completed when sexual stages (known as gametocytes), which also develop in RBCs, are transmitted to a biting mosquito that is taking a blood meal.