NIH Director's Transformative Research Award Program

2011 Transformative R01 Award Recipients

NOTE: Click on any thumbnail image to see entire figure with description.
Full descriptions are available for those projects with a released Notice of Grant Award.

Microfluidic platform for testing novel drug treatments for aging and neurodegenerative diseases (Click for large image and detailed description)

Adela Ben-Yakar, Ph.D. and Jonathan T. Pierce-Shimomura, Ph.D.
University of Texas at Austin
Project Title:High-Speed Opto-Fluidics To Screen Entire Nervous System In Aging And Disease

Movements of a computer cursor (shown as a blue line) controlled by a brain-computer interface (Click for large image and detailed description)

Kwabena Boahen, Ph.D.
Stanford University
Project Title: Fully Implantable And Programmable Spike-Based Codecs For Neuroprosthetics

Fighting cancer by inhibiting desuccinylation of metabolic enzymes (Click for large image and detailed description)

Richard Cerione, Ph.D., Hening Lin, Ph.D., and Robert Weiss, Ph.D.
Cornell University
Project Title: Succinylation And Malonylation As Novel Protein Modifications In Cancer

Identical twins are pictured in the foreground, while multi-colored neurons are depicted in the background (Click for large image and detailed description)

Fred Gage, Ph.D.
The Salk Institute
Project Title: Single-Cell Approaches To Reveal How Jumping Genes Individualize Neural Circuits


Outside-of-the-box toxicity testing for chemicals without the use of animals (Click for large image and detailed description)

Thomas Hartung, M.D., Ph.D.
Johns Hopkins University Bloomberg School of Public Health
Project Title: Mapping The Human Toxome By Systems Toxicology

Schematic of using bacterial genes to engineer human immune cells to “eat” cholesterol (Click for large image and detailed description)

Richard Honkanen, Ph.D.
University of South Alabama School of Medicine
Project Title: Methods To Enable Cholesterol Catabolism In Human Monocyte Derived Macrophages

Micron-scale circuits (green) will be designed to adhere to brain cells and convert neural voltage signals into magnetic fields detectable by imaging (Click for large image and detailed description)

Alan Jasanoff, Ph.D.
Massachusetts Institute of Technology
Project Title:Noninvasive Imaging-Based Electrophysiology Using Microelectronic Devices

Tissue Resident Memory T Cells (TRM) generated by skin vaccination (Click for large image and detailed description)

Thomas Kupper, M.D.
Brigham and Women's Hospital / Dana Farber Brigham and Women's Cancer Center / Harvard Medical School
Project Title: Vaccination To Generate Protective Tissue Resident T Cells

This innovative treatment for Attention Deficit Hyperactivity Disorder (ADHD) combines cognitive and physical exercises to activate and strengthen under-developed brain systems necessary for sustained attention and self-regulation (Click for large image and detailed description)

James Leckman, M.D. and Bruce Wexler, M.D.
Yale University
Project Title: Integrated Brain, Body, And Social Intervention For ADHD

Color-coded reconstruction of three neurons (Click for large image and detailed description)

Jeff Lichtman, M.D., Ph.D., Markus Meister, Ph.D., and Joshua Sanes, Ph.D.
Harvard University
Sebastian Seung, Ph.D.
Massachusetts Institute of Technology
Project Title:High Resolution Connectomics Of Mammalian Neural Circuits

Microscale materials (green) entrapped within aggregates of stem cells. (Click for large image and detailed description)

Todd McDevitt, Ph.D.
Georgia Institute of Technology / Emory University
Project Title:Stem Cell Morphogen Delivery via Engineered Biomaterials

Electron micrograph of mitochondria purified from heart (Click for large image and detailed description)

Vamsi Mootha, M.D.
Massachusetts General Hospital / Harvard Medical School
Project Title: Molecular Prostheses For Mitochondrial Disorders

Diagram of an integrated multichannel imaging system for intraoperative cancer detection and image-guided surgery (Click for large image and detailed description)

Shuming Nie, Ph.D.
Emory University / Georgia Institute of Technology
Sunil Singhal, M.D.
University of Pennsylvania School of Medicine
Project Title: Contrast-Enhanced And Image-Guided Surgery Of Lung Cancer

Mesenchymal stem cell (MSC) pictured on the bottom transferring red dye - labeled small interfering RNA into a target neuronal cell (arrow). (Click for large image and detailed description)

Jan Nolta, Ph.D.
University of California, Davis
Project Title: Direct Cell To Cell Transfer Of MicroRNA For Tissue Repair

Trypanosomes and immune cells (B cells) (Click for large image and detailed description)

F. Nina Papavasiliou, Ph.D.
Rockefeller University
Project Title: Building Novel Vaccines On A Borrowed Coat

Single molecule translational profiling

Joseph D. Puglisi, Ph.D
Stanford University School of Medicine
Project Title: Single Molecule Translational Profiling

MRI of patient with spina bifida (arrow) (Click for large image and detailed description)

Margaret Elizabeth Ross, M.D., Ph.D. and Christopher E. Mason, Ph.D
Weill Medical College of Cornell University
Project Title: Epigenome Interactions In Complex Neurogenetic Disorders





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Division of Program Coordination, Planning, and Strategic Initiatives  •  National Institutes of Health  •  Bethesda, Maryland 20892