Development of High Throughput Aptamer-based Protein Capture/Detection Assays towards Comprehensive Analysis of Human Proteome
The schematics of multiplexed microfluidic SELEX. Aptamers in a randomized nucleic acid (NA) pool will bind target proteins confined in sol-gel spots on the microfluidic device, protein-bound aptamers will be thermally eluted by integrated aluminum electrodes. Then, selected aptamers are either reamplified and used for the next round of SELEX or identified by massively parallel sequencing.
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