Molecular Libraries and Imaging

Science Publications




List of all program publications:
 
Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters.
Strouse, J Jacob; Ivnitski-Steele, Irena; Waller, Anna; Young, Susan M; Perez, Dominique; Evangelisti, Annette M; Ursu, Oleg; Bologa, Cristian G; Carter, Mark B; Salas, Virginia M; Tegos, George; Larson, Richard S; Oprea, Tudor I; Edwards, Bruce S; Sklar,
Analytical biochemistry. 2013 Jun 1. 77-87 
PMID: 23470221 [PubMed]
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening.
Thomas, Pei W; Spicer, Timothy; Cammarata, Michael; Brodbelt, Jennifer S; Hodder, Peter; Fast, Walter
Bioorganic & medicinal chemistry. 2013 Jun 1. 3138-46 
PMID: 23591260 [PubMed]
Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN
Engers, Darren W; Frist, Audrey Y; Lindsley, Craig W; Hong, Charles C; Hopkins, Corey R
Bioorganic & medicinal chemistry letters. 2013 Jun 1. 3248-52 
PMID: 23639540 [PubMed]
A small molecule inhibitor of fungal histone acetyltransferase Rtt109.
Lopes da Rosa, Jessica; Bajaj, Vineeta; Spoonamore, James; Kaufman, Paul D
Bioorganic & medicinal chemistry letters. 2013 May 15. 2853-9 
PMID: 23587423 [PubMed]
Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C-H activation.
Yu, Yi-Yun; Georg, Gunda I
Chemical communications (Cambridge, England). 2013 May 7. 3694-6 
PMID: 23529083 [PubMed]
High-Throughput Screen for Pharmacoperones of the Vasopressin Type 2 Receptor.
Conn, P Michael; Smith, Emery; Hodder, Peter; Janovick, Jo Ann; Smithson, David C
Journal of biomolecular screening. 2013 May 2. NULL 
PMID: 23640875 [PubMed]
Spiroaminal Model Systems of the Marineosins with Final Step Pyrrole Incorporation.
Panarese, Joseph D; Konkol, Leah C; Berry, Cynthia B; Bates, Brittney S; Aldrich, Leslie N; Lindsley, Craig W
Tetrahedron letters. 2013 May 1. 2231-2234 
PMID: 23606772 [PubMed]
Molecular sentinel-on-chip for SERS-based biosensing.
Wang, Hsin-Neng; Dhawan, Anuj; Du, Yan; Batchelor, Dale; Leonard, Donovan N; Misra, Veena; Vo-Dinh, Tuan
Physical chemistry chemical physics : PCCP. 2013 Apr 28. 6008-15 
PMID: 23493773 [PubMed]
Heterocycle-Heterocycle Strategies: (2-Nitrophenyl)isoxazole Precursors to 4-Aminoquinolines, 1H-Indoles, and Quinolin-4(1H)-ones.
Coffman, Keith C; Palazzo, Teresa A; Hartley, Timothy P; Fettinger, James C; Tantillo, Dean J; Kurth, Mark J
Organic letters. 2013 Apr 19. 2062-5 
PMID: 23557405 [PubMed]
A small molecule inhibitor of redox-regulated protein translocation into mitochondria.
Dabir, Deepa V; Hasson, Samuel A; Setoguchi, Kiyoko; Johnson, Meghan E; Wongkongkathep, Piriya; Douglas, Colin J; Zimmerman, Johannes; Damoiseaux, Robert; Teitell, Michael A; Koehler, Carla M
Developmental cell. 2013 Apr 15. 81-92 
PMID: 23597483 [PubMed]
Mooreia alkaloidigena gen. nov., sp. nov. and Catalinimonas alkaloidigena gen. nov., sp. nov., alkaloid-producing marine bacteria in the proposed families Mooreiaceae fam. nov. and Catalimonadaceae fam. nov. in the phylum Bacteroidetes.
Choi, Eun Ju; Beatty, Deanna S; Paul, Lauren A; Fenical, William; Jensen, Paul R
International journal of systematic and evolutionary microbiology. 2013 Apr. 1219-28 
PMID: 22753528 [PubMed]
Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis.
Florian, Amy E; Lepensky, Christopher K; Kwon, Ohyun; Haynes, Mark K; Sklar, Larry A; Zweifach, Adam
Journal of biomolecular screening. 2013 Apr. 420-9 
PMID: 23160568 [PubMed]
A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.
Noetzel, M J; Gregory, K J; Vinson, P N; Manka, J T; Stauffer, S R; Lindsley, C W; Niswender, C M; Xiang, Z; Conn, P J
Molecular pharmacology. 2013 Apr. 835-47 
PMID: 23348500 [PubMed]
Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present).
Zak, Krzysztof; Pecak, Aleksandra; Rys, Barbara; Wladyka, Benedykt; Domling, Alexander; Weber, Lutz; Holak, Tad A; Dubin, Grzegorz
Expert opinion on therapeutic patents. 2013 Apr. 425-48 
PMID: 23374098 [PubMed]
Intermolecular C-O Addition of Carboxylic Acids to Arynes: Synthesis of o-Hydroxyaryl Ketones, Xanthones, 4-Chromanones, and Flavones.
Dubrovskiy, Anton V; Larock, Richard C
Tetrahedron. 2013 Apr 1. 2789-2798 
PMID: 23520410 [PubMed]
Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87-MG Glioblastoma Cells.
O'Reilly, Matthew C; Scott, Sarah A; Brown, Kyle A; Oguin 3rd, Thomas H; Thomas, Paul G; Daniels, J Scott; Morrison, Ryan; Brown, H Alex; Lindsley, Craig W
Journal of medicinal chemistry. 2013 Mar 28. 2695-9 
PMID: 23445448 [PubMed]
A General, Enantioselective Synthesis of 1-Azabicyclo[m.n.0]alkane Ring Systems.
Senter, Timothy J; Schulte, Michael L; Konkol, Leah C; Wadzinski, Tyler E; Lindsley, Craig W
Tetrahedron letters. 2013 Mar 27. 1645-1648 
PMID: 23459400 [PubMed]
EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold.
Jiang, Wei; Cacho, Ralph A; Chiou, Grace; Garg, Neil K; Tang, Yi; Walsh, Christopher T
Journal of the American Chemical Society. 2013 Mar 20. 4457-66 
PMID: 23451921 [PubMed]
Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist.
Chen, Haijun; Ding, Chunyong; Wild, Christopher; Liu, Huiling; Wang, Tianzhi; White, Mark A; Cheng, Xiaodong; Zhou, Jia
Tetrahedron letters. 2013 Mar 20. 1546-1549 
PMID: 23459418 [PubMed]
Discovery of ML326: The first sub-micromolar, selective M5 PAM.
Gentry, Patrick R; Bridges, Thomas M; Lamasal, Atin; Vinson, Paige N; Smith, Emery; Chase, Peter; Hodder, Peter S; Engers, Julie L; Niswender, Colleen M; Scott Daniels, J; Jeffrey Conn, P; Wood, Michael R; Lindsley, Craig W
Bioorganic & medicinal chemistry letters. 2013 Mar 16. NULL 
PMID: 23562060 [PubMed]
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Division of Program Coordination, Planning, and Strategic Initiatives  •  National Institutes of Health  •  Bethesda, Maryland 20892