• Agenda   
• Participants   
• Meeting Synopsis   

Agenda

Day 1: December 15, Wednesday
7:30 a.m.	Registration & Continental Breakfast
7:45 a.m. - 8:15 a.m.	Informal NIH - ESP Executive Session Room: Lincoln
8:30 a.m.	Welcome and Programmatic Items
8:45 a.m.	GTEx Goals and Milestones - Jeff Struewing, NHGRI Briefly review GTEx goals, milestones and overall project timeline
MILESTONE 1 – Donor Enrollment
9:00 a.m.	Donor Demographics and Clinical Data - Carolyn Compton, caHUB Donor enrollment rates, projections; donor summaries
9:30 a.m.	GTEx Donor Consent Sub-Study - Laura Siminoff, VCU Preliminary results
10:00 a.m.	Milestone 1: Discussion and Q&A Session
10:30 a.m.	Coffee Break
MILESTONE 2 – Molecular and Tissue Quality
10:45 a.m.	Molecular Quality - Kristen Ardlie, Broad Institute, Wendy Winckler, Broad Institute Summary of sample RINs and yield trends; gene expression metrics
11:15 a.m.	GTEx Project - Pathology Resource Center Update - Les Sobin, caHUB Summary of histopathological findings and RIN analysis
11:45 a.m.	Milestone 2: Discussion and Q&A Session
12:15 p.m.	Lunch (boxed or on own)
MILESTONE 3 – Statistical Analyses
1:00 p.m.	eQTL Analyses - David Deluca, Broad Institute, Gad Getz, Broad Institute Preliminary eQTL analyses; collaboration plans with Statistical Methods R01s What would be the most compelling preliminary eQTL results?
1:30 p.m.	GTEx Data Release - Taylor Young, Broad Institute, Simona Volpi, NHGRI
2:00 p.m.	Milestone 3: Statistical Methods Discussion and Q&A Session
2:30 p.m.	Wrap-up /Action Items Summary - Simona Volpi, NHGRI
3:00 p.m.	Coffee Break - General Session ADJOU
3:15 p.m.	Suggested informal discussions Room: Regency (main room) A. BSS quality metrics going forward B. Analysis pipeline - Broad/Statistical methods PIs Analysis plan discussion Scale-up power considerations - how large should a scale-up be?
3:30 p.m.	NIH – ESP Executive Session Room: Lincoln
Day 2: Friday, December 2, 2011
8:00 a.m.	Continental Breakfast
8:30 a.m.	Impressions from ESP/Programmatic Items - Su Koester, NIMH
9:00 a.m.	Biospecimen Methodological Study - Chana Rabiner, caHUB
9:30 a.m.	Group Discussions A. Biospecimen Collection Moderators: Les Sobin and Jeff Thomas Room: Regency (main room) Procurement issues Fixation Doubling of aliquots (contiguous samples) Sampling problems (fat, mucosa vs muscle, etc) Fixation-stabilization ‘mix-up’ Proposed modification of tissue procurement Tissues to be eliminated and added B. Data Collection Moderators: Barbara Foster, Sherilyn Sawyer and Laura Siminoff Room: Lincoln Time of data collection Elements of difficult abstraction Additional elements to consider Consent - Problems or issues in obtaining consent for GTEx participation C. Data Analysis Moderators: Gad Getz Room: Randolph
10:15 a.m.	Coffee Break and time for checkout
10:45 a.m.	Group Discussions D. Biospecimen Logistics Moderators: Steve Buia, Dan Rohrer and Scott Jewel Room: Regency (main room) Handling Timelines Workflow Lessons learned as relate to scale-up E. Informatics and data transfer Moderators: Alex Thompson, Taylor Young and Charlie Shive Room: Lincoln Review of current data flow Discussion of project analysis Lessons learned as relate to scale-up trategic planning discussion What needs to be done to have a cleaned set of data for submission to dbGaP
11:30 a.m.	Break - Working Group Summaries & Wrap-Up 10-min presentations by moderators + 5-min Q&A
12:30 p.m.	Summary of GTEx’s next steps - Jeff Struewing, NHGRI
1:00 p.m.	ADJOURN - Thank you

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