• Agenda   
• Participants   
• Meeting Synopsis   

Agenda

For additional information, please contact Cathy Ng at GTEXInfo@mail.nih.gov.

Day 1: June 7, Tuesday
Donor Recruitment/Tissue Collection
7:30 a.m.	Registration and Continental Breakfast Informal ESP (External Scientific Panel) Executive Session (breakout room)
8:30 a.m.	Welcome & Opening Comments Jeff Struewing External Scientific Panel (ESP) members
9:00 a.m.	Donor Enrollment and Tissue Collection Summaries: Pilot and Beta Biospecimen Source Sites (BSS) – National Disease Research Interchange (NDRI), Roswell Park Cancer Institute (RPCI), Science Care
9:45 a.m.	Optimizing Specimen Collections Jim Vaught Greg Korzeniewski Cancer Human Biobank (caHUB)/NHGRI Partnership Overall Specimen Collection Process Experiment & Beta Collections Lessons Learned CDR/Source Site Status
10:35 a.m.	Break
10:50 a.m.	Preliminary Molecular Results Kristin Ardlie Wendy Winckler
11:05 a.m.	CBR Integration and Roles Scott Jewell
11:35 a.m.	caHUB Pathology Les Sobin Review Update/Prelim Results Experience with PAXgene
12:05 p.m.	Lunch
1:05 p.m.	Donor Consent/Human Subjects Issues (ELSI sub-study) Laura Siminoff
1:35 p.m.	ELR Update Anna Smith
1:50 p.m.	Small Group Session 1 Case Report Form (CRF) Data Elements (review of clinical data captured (post-mortem and surgical), reporting and exchange) (Group Leader: Mary Kennedy) Donor Inclusion/Exclusion Criteria and Human Subjects (Group Leader: Angela Zimmerman) Informatics Topics (ID generation by LDACC, Data exchange between CDR and LDACC, Data Submission plans, Data flow problems, caTissue use and plans) (Group Leader: Alex Thomson)
2:40 p.m.	Break
2:55 p.m.	Small Group Session 2 Critical CHP Processes and Timelines (Chain of Custody, Shipping, Logistics) (Group Leader: Steve Buia) Kits/Tissue SOPs (Group Leader: Scott Jewell) Data Analysis (data formats, submissions, and metrics) (Group Leader: Gad Getz)
3:45 p.m.	Reconvene for Small Group Summaries, Timeline, Action Items Discussion
4:30 p.m.	Reaction/Feedback from ESP ESP Members
4:45 p.m.	Adjourn ESP Executive Session with Eric Green

Day 2: June 8, Wednesday
Molecular and Statistical Analysis How do we optimize the analysis of GTEx data? How do we make the data and results maximally useful to the scientific community?
7:30 a.m.	Registration and Continental Breakfast
8:30 a.m.	LDACC Kristin Ardlie Wendy Winckler Data generation plans (array selections, sequencing methods, etc) Analytical pipeline cis-eQTL analysis plans
9:15 a.m.	Q&A/Discussion
9:30 a.m.	Analysis Plans Common Fund Supported R01 Investigators Nancy Cox, Dan Nicolae Emmanouil Dermitzakis, Roderic Guigo, Daphne Koller, Mark McCarthy
10:30 a.m.	Break
10:45 a.m.	Analysis Plans (Cont’d.) Common Fund Supported R01 Investigators Jun Liu, Jun Zhu Jonathan Pritchard Ivan Rusyn, Andrew Nobel, Fred Wright
12:15 a.m.	Working Lunch: Discussion/Brainstorming
1:00 p.m.	Batch Effects Jeff Leek
1:30 p.m.	Integration of GTEx data into genome browsers and other public resources NCBI – Nataliya Sharopova Ensembl – Misha Kapushesky Integrative Genomics Viewer – Gad Getz
2:00 p.m.	Using gene expression QTL’s to guide functional studies after GWAS Marie Fogarty
2:15 p.m.	NCIs repurposing of caHUB; Continued Investment in GTEx Carolyn Compton
2:45 p.m.	Discussion & Wrap-up/Comments ESP Members
3:15 p.m.	Adjourn

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