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Agenda

For additional information about the Workshop, please contact either Cristen Robinson or Anna Rossoshek at GTEXInfo@mail.nih.gov.

Day 1: June 2, Monday
8:00 a.m. Continental Breakfast
8:30 a.m. Francis Collins: Welcome and Introduction to Aims of GTEx Proposal
9:00 a.m. GWAS studies, eQTLs, and Beyond
Cliona Molony
John Hardy
Discussion
10:00 a.m. Coffee Break
10:30 a.m. Challenges of Obtaining Multiple, High-Quality Tissues for GTEx
Carolyn Compton
Mark Rubin
John Lonsdale
Discussion
11:30 a.m. Lunch
12:30 p.m. Consideration of Ethical, Legal, and Social Implications (ELSI)
Stuart Youngner
Laura Beskow
Discussion
  Breakout Sessions
Most groups will be run twice, with different leaders and a different mix of people. Each group/session has an assigned note-taker and assigned leader. ELSI will be integrated into all group discussions
1:30 p.m. Breakout Session I

Group A: Statistical/Epidemiology Issues; Size, Statistical Power, Phenotypic Variables, Analytical Plans (Group Leaders: Nancy Cox, Manolis Detmitzakis, Richard Spielman)

Group B: Building a Public Database of eQTL Data: Access and Analytical Tools (Group Leader: Ron Edgar)

Group C: Procuring Tissues of High Quality: Setting Quality Standards (Group Leader: Ron Zielke)

Group D: Laboratory Analysis of Tissues for Global RNA Expression: Methods and Quality Standards (Group Leaders: Martin Hirst)

3:00 p.m. Coffee Break
3:30 p.m. Breakout Session II: (Most participants from Session I will join different groups in Session II.)

Group A: Break into 2-3 sub-groups based on discussion during Session I
» A1 sub-topic to be determined in Session I (Nancy Cox)
» A2 sub-topic to be determined in Session I (Manolis Dermitzakis)
» A3 sub-topic to be determined in Session I (Richard Spielman)

Group C: Procuring Tissues of High Quality: Setting Quality Standards (Group Leader: Mark Sobel)

Group D: Laboratory Analysis of Tissues for Global RNA Expression: Methods and Quality Standards (Group Leader: John Walker)

5:00 p.m. Group Leaders and Scribes Review and Consolidate Notes
6:00 p.m. Meet and Greet (Atrium)
Day 2: Tuesday, June 3
8:00 a.m. Continental Breakfast
8:30 a.m. Summarizing Results of Breakout Sessions
8:30 a.m. Group A Leaders
9:00 a.m. Group B Leaders
10:00 a.m. Coffee Break
10:15 a.m. Group C Leaders
11:15 a.m. Group D Leaders
12 noon Lunch
1:30 p.m. Drafting Recommendations for GTEx Proposal (30 minutes each)
Chair: Francis Collins

» Statistical/Epidemiology Issues
» Public Database
» Tissue Procurement
» ELSI Considerations
» Data Quality Standards
» Laboratory Analyses
3:30 p.m. End of Workshop
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