of Program Coordination, Planning, and Strategic Initiatives
3/6/2012 4:50:54 PM #
The membrane composition of exosomes should be determined so similar structures could be made from synthetic (pure) components. While naturally made exosomes are useful research tools, exosome mimetic structures would make the studies less of a "black box" as well as pave the way for eventual clinical studies.
3/19/2012 1:45:37 AM #
Potential to use as biomarker if the technology is developed to isolate and characterize these.
3/20/2012 4:50:15 AM #
Exosomes first application in clinical use will be in diagnostics. Aready there are many groups working on with a focus on cancer and several other diseases. The possibility to effectively use exosomes in diagnostics are related to the development of immunocapturing methods and immunometric mulpitlex assays.
5/3/2012 6:31:39 AM #
There are several studies (presented at ISEV 2012) describing use of exosomes- for example from certain stem cell populations as therapeutics. Whilst there are some striking effects on multiple cellular components in many of these studies- there currently is a lack of understanding in terms of mechanism, and a lack of appreciation about exosome-target cell selectivity in such studies. Also potential adverse effects are rarely mentioned.So, I think we do need to strive forward with these studies, but in a more mechanism-driven manner. Having tools to examine exosome-target cell interactions, and selective cargo-delivery will be key to future success of these studies. Also of course in depth understanding of a cell's response to exosome interaction will be essential. We must keep in mind that these are not biologically inert entities- and they could cause harm, or unexpected physiological effects.It is likely that just one adverse reaction using an exosome-therapeutic in humans may be enough to suffocate developments in this field- as we have seen many such examples of this in the context of cancer immuno-therapy. Hence a cautious approach is probably better for the field as a whole.
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