The Common Fund's Epigenomics Program includes a series of complementary initiatives aimed at generating new research tools, technologies, datasets, and infrastructure to accelerate our understanding of how genome-wide chemical modifications to DNA regulate gene activity without altering the DNA sequence itself and what role these modifications play in health and disease.
A Scientific Illustration of How Epigenetic Mechanisms Can Affect Health
NEW! Functional Epigenomics Awards Announced!
The Epigenomics program has announced awards for Functional Epigenomics: Developing Tools and Technologies for Cell-type, Temporal, or Locus-specific Manipulation of the Epigenome (RM-RFA-12-026). This initiative addresses a critical need for tools and technologies to enable precise manipulation of the epigenome in order to discover fundamental biological principles, as well as develop novel epigenomic therapeutics.
Read about the Funded Research
Jumping genes have a job to do
Common Fund Researchers Detail Epigenomic Changes during Development
Epigenomics researchers publish new study linking genetic variation and gene regulation in many common diseases
Epigenomics researchers uncover new chemical modifications on DNA associated proteins
Tips and Tools for Using Epigenomics Resources
NEW! Browsing (Epi)genomes: A Guide to Data Resources and Epigenome Browsers for Stem Cell Researchers
NEW! ENCODE and Roadmap Epigenomics Mapping Center combined data browser
ENCODE/Roadmap Epigenomics Tutorial
A Guide to the Epigenome
Epigenomics: The New Technologies of Chromatin Analysis
Overview of Epigenomics program resources
Watch Epigenomics grantee John Stamatoyannopoulos’ lecture “A Roadmap to the Living Genome,” in which he presents research describing new epigenomic maps for a wide variety of normal human cell/tissue types; insights into the genomic patterning of epigenomic features; and encoding of cellular state, maturity, and fate information within epigenomic landscapes.
Watch “A Roadmap to the Living Genome” video here.
Download slides from the Epigenomics presentation to the NIH Council of Councils
Download slides here
Epigenomes Around the WorldThe Epigenomics Program is part of the International Human Epigenome Consortium that aims to coordinate worldwide epigenome mapping and characterization efforts.